Moderna HIV Vaccine Phase 1 Human Trials to Start as Early as Next Week. Hope to Build on mRNA Learnings

Minnesota AIDS Project
Photo: Wikimedia Commons

The Moderna HIV vaccine is set to enter human trials as early as next week, marking a monumental step in the treatment of one of the most devastating health crises worldwide.

According to the National Institutes of Health’s clinical trials registry, the biotech company is prepping to test its mRNA-1644 and mRNA-1644v2-Core vaccines after both passed phase one testing earlier this year. The study will divide its 56 participants, all of which have not previously tested positive for HIV, into four groups that will be administered both or either vaccine in various combinations.

Building the vaccine from an mRNA foundation differs from previous vaccine constructions and functionality, essentially providing instructions for cells to build immune responses through specific protein production. This process teaches the body how to defend itself on the cellular level rather than having human immune systems learn through combating weakened forms of a virus.

mRNA vaccines also respond better to variants of a virus – a fact that is…

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